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What Causes Autism?

Mixed Explanations and Theories
Medically reviewed by Kira Graves, PhDMedically reviewed by Kira Graves, PhDWith more attention being paid to spectrum disorders including autism, and a noticeable increase in autism diagnoses, you may be wondering what causes autism and is autism genetic or environmental. Causes of autism are complex and explored ahead. This article will also discuss why some children and adults have different levels of autism as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).

juanma hache / Getty Images

Related: Autism
Autism, Causes, and the BrainThere is no known root cause or a single cause of autism, and both genetic and environmental factors are involved. Research in the past decade has identified hundreds of genes contributing to communication, social cognition, and behavioral differences present in autism spectrum disorder (ASD). According to a 2019 medical review on genetic causes of autism, these genes may be inherited (passed down in families) or show up in genetic variations not previously seen in the family.
TakeawayGenes account for 10% to 20% of autism cases, and people with similar gene variations can have varying levels of autism support needs, according to the same review.
Other factors associated with autism include:  Advanced or older parental ageVery low birth weightExtremely premature birthNeonatal jaundice  (having a high level of bilirubin, a blood waste product, at birth)Pregnancy complicationsBirthing complications Immune system disordersTraffic-related air pollutants associated with genetic mutation Excessive parental stressEmotional injury or trauma
Factors That Do Not Cause AutismExperts say more research is needed before establishing a causal relationships. These factors alone do not “cause” autism, but may contribute to autism development when combined and paired with certain genetic factors. Excessive parental stress, for example, may have some negative impact on healthy development, but it does not directly cause autism.
What Is KnownResearchers describe autism as a neurodevelopmental disorder with causes linked to a complex combination of genetics and environmental factors. They also acknowledge the causes of autism are more complicated than that. Parenting style does not cause autism, and parents don’t cause the difficulties associated with autism.
Vaccines Do Not Cause AutismThere is no known link between autism and vaccines, including those containing the mercury-based compound thimerosal.
What Is Not KnownThere is no consensus on what causes autism.Some people with autism have higher support needs than others, although it isn’t always clear why. The amount of support a person with autism needs may vary. A combination of factors is likely at play. For example, if someone has a comorbid condition (a co-occurring health condition), such as a learning disability and/or psychiatric condition, it may compound support needs and accommodations. 
What Is Masking?Masking is a term used to describe how autistic people hide parts of themselves to blend into society better.
Who Is More Likely to Develop Autism?Autism is found across genders, races, ethnicities, and economic backgrounds. People who may be more likely to develop autism include those with:Older parentsA sibling with autismVery low birth weight (premature birth)Certain genetic conditions including Down syndrome 
Related: 6 Health Conditions Common in Autism

What Are Autism Levels?Autism levels refer to different levels of support needs seen in across the autism spectrum, and are as follows:Level 1: Requires support (e.g., hard time communicating with people, including peers, task switching, and organizing challenges)Level 2: Requires substantial support (e.g., harder time masking, repetitive behaviors, unpopular specific interests)Level 3: Requires very substantial support (e.g., unable to mask, self-regulation challenges including severe and obvious symptoms like head banging or going nonverbal)

Related: Do Autism Traits Go Away Over Time?
Pregnancy and Autism CausesDuring pregnancy, metabolic conditions like excessive pregnancy weight gain, obesity, and gestational diabetes (diabetes during pregnancy) are associated with glucose metabolism dysfunction, affecting brain energy production. One 2019 study suggests metabolic disorders like hypoglycemia (low blood glucose) during pregnancy may be a contributing factor to a child having autism. High blood sugar or hyperglycemia after birth may also play a role, according to the same study.Other pregnancy complications contributing to (but not causing) the risk of autism include:FeverExposure to contaminants causing genetic mutations in the childBirthing complications, including a reduced oxygen supply to the child’s brain. When pregnant, inform your healthcare provider of any medications you are taking. One anti-seizure medication Valporaote (depakene), in particular, is associated with an increased chance of autism development in the child.
Pregnancy and Antidepressants and AutismPrevious research on pregnancy, antidepressants, and autism is limited and with conflicting findings. Importantly, one large meta-analysis published in 2022 found no association between antidepressant use during pregnancy and autism development in the child.

Related: Autism Risks Related to Pregnancy and Birth
Causes of Undiagnosed Autism in Adults Autism can go undiagnosed for several reasons. It can be mistaken for mental health disorders such as:Obsessive-compulsive disorder (OCD)Social anxiety disorder (SAD)Separation anxiety disorderAttention-deficit hyperactivity disorder (ADHD)Additionally, autism's diagnostic criteria were revised in the DSM-5, meaning people born before these revisions may have gone undiagnosed.
Mental Health SupportIf you or a loved one needs mental health support, contact the Substance Abused and Mental Health Services Administration (SAMHSA) National Hotline for treatment and support group referrals at 800-662-HELP (4357). If you are having suicidal thoughts, dial 988 to contact the 988 Suicide & Crisis Lifeline and connect with a trained counselor. If you or a loved one is in immediate danger, call 911.
Gender DisparitiesResearchers argue there has been a gender gap in autism research and understanding that lead to more men being diagnosed with autism and women frequently being undiagnosed. This has led to a biased, male-centric understanding of autism and created barriers to understanding how autism develops in girls and women.
Related: Who Should Diagnose Autism Spectrum Disorder?

Gender Dysphoria and AutismGender dysphoria (discomfort with the gender one was assigned at birth) and autism often co-occur. Gender dysphoria has been said to create challenges for healthcare providers in diagnosing autism.

Related: Differences in Diagnosing Autism in Girls and Boys
Racial DisparitiesResearch shows systematic racial bias and cultural misperceptions result in missed autism diagnosis and underdiagnosis in Black, Latinx, and Asian children—and that children of color are not being diagnosed until later in life, if at all.
Why Early Diagnosis MattersEarly diagnosis and treatment are crucial factors in optimizing autism outcomes including accessing the right supports, reducing stress, and increasing independence in adulthood. Delayed or missed diagnosis is detrimental to outcome.

Related: What Does 'Neurodivergent' Mean?
SummaryAutism can develop in anyone, but there are several genetic and environmental factors contributing to it. More research is needed to understand the root causes of autism. Changes in diagnostic criteria and gender and racial disparities have caused people to go undiagnosed. Read the original article on Verywell Health.

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